Science

Trimer-Tag™ Technology Platform

The Trimer-Tag™ technology platform is a product development platform for the creation of novel vaccines and biologic therapies. The Trimer-Tag™ technology platform can trimerize* any protein of interest and target a broad spectrum of naturally trimerization-dependent disease and biologic targets. By employing the Trimer-Tag™ technology platform, we are able to produce innovative, covalently-trimerized fusion proteins to effectively target previously difficult to target pathways.

The following diagram highlights the Trimer-Tag™ technology platform and the naturally trimerization-dependent disease and biologic targets that could potentially be addressed by harnessing our technology:

Key Features of the Trimer-Tag™ Technology Platform

  • Platform for development of protein-based vaccines and immuno-oncology therapies based on naturally trimerization-dependent targets.
  • Only trimerization technology platform globally for producing recombinant covalently-trimerized fusion proteins utilizing a human-derived trimerization tag.
  • Platform validation demonstrated for vaccines (Global SPECTRA Ph 2/3 Data for SCB-2019) and oncology (Ph 1 Interim Data for SCB-313).

* A “trimer” refers to a molecule or an anion formed by combination or association of three molecules or ions of the same substance. Trimerization is a chemical reaction that uses three identical molecules to produce a single trimer. Proteins that are created through the joining of two or more genes that originally coded for separate proteins and consist of three identical simpler parts are referred to as “trimeric fusion proteins.” Trimerization tag refers to a protein tag from the C-propeptide domain of procollagen (Trimer-Tag™), which is capable of self-assembly into a disulfide bond-linked trimer.