About Us

About Clover Biopharmaceuticals
Founded in 2007, we are a global clinical-stage biotechnology company committed to developing novel vaccines and biologic therapeutic candidates. Our vision is to empower humanity with a healthier future through transformative science. Our mission is to leverage the Trimer-Tag™ technology platform and manufacturing capabilities for the discovery, development and commercialization of novel vaccines and biologic therapies.

From GenHunter, we in-licensed the Trimer-Tag™ technology platform, a product development platform for the creation of novel vaccines and biologic therapies. We have leveraged the Trimer-Tag™ technology platform to become a COVID-19 vaccine developer and created SCB-2019 (CpG 1018/Alum) to address the COVID-19 pandemic caused by SARS-CoV-2.

The Trimer-Tag™ technology platform can trimerize* any protein of interest and target a broad spectrum of naturally trimerization-dependent disease and biologic targets. These include dozens of enveloped RNA viruses (e.g. coronaviruses, rabies, respiratory syncytial virus (RSV), influenza, human immunodeficiency virus (HIV), and Ebola) and the tumor necrosis factor (TNF) superfamily (TNFSF), which have diverse biological functions and are linked to serious diseases, such as certain cancers and autoimmune disorders.

Globally, Trimer-Tag™ is the only trimerization technology platform for designing and producing recombinant, covalently-linked, trimeric fusion proteins (trimer-tagged proteins) exploiting a human-derived trimerization tag. The trimer-tagged proteins produced by the Trimer-Tag™ technology platform have high potency against trimerization-dependent disease targets and favorable safety profiles.

We have built our product pipeline by employing the Trimer-Tag™ technology platform and leveraging our in-house biologics manufacturing infrastructure and capabilities.

* A “trimer” refers to a molecule or an anion formed by combination or association of three molecules or ions of the same substance. Trimerization is a chemical reaction that uses three identical molecules to produce a single trimer. Proteins that are created through the joining of two or more genes that originally coded for separate proteins and consist of three identical simpler parts are referred to as “trimeric fusion proteins.” Trimerization tag refers to a protein tag from the C-propeptide domain of procollagen (Trimer-Tag), which is capable of self-assembly into a disulfide bond-linked trimer.