Trimer-Tag™ Oncology

Clover has successfully utilized the Trimer Tag™ technology platform to design and develop SCB-313 as a covalently-linked, native-like trimeric fusion protein which is structurally and functionally differentiated from the dimeric antibody-based structures and other native ligand-based candidates targeting this pathway. We believe SCB-313 has the potential to address the unmet global need for the treatment of intracavitary malignancies, including MA, MPE, and PC, as well as additional cancer indications.

Clover is exploring other targets in the TNFSF for immuno-oncology and immunology indications. We are currently conducting discovery programs evaluating trimeric fusion protein candidates targeting the 4-1BB pathway, a member of the TNFSF.